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Medchemexpress LLC 1(2H)-Phthalazinone, 4-(1,3-dioxan-2-ylmethyl)-2-[[4-(4-methylphenyl)-2-thiazolyl]methyl]- | 1614225-93-2 | 99.3% | 50 MG
SDP

Supplier:  Medchemexpress LLC HY12859050MG

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PHT-7.3 is a selective inhibitor of connector enhancer of kinase suppressor of Ras 1 (Cnk1) pleckstrin homology (PH) domain (Kd=4.7 μM). It inhibits mutant KRas, but not wild-type KRas cancer cell and tumor growth and signaling, and exhibits antitumor activity. In vivo studies show that PHT-7.3 demonstrates cytostatic antitumor activity in mut-KRas(G12S) A549 xenograft and mut-KRasG12V H441 xenograft models.

  • Selective inhibitor of Cnk1 PH-domain (Kd=4.7 μM).
  • Inhibits mutant-KRas cancer cell and tumor growth and signaling.
  • Exhibits antitumor activity.
  • Demonstrates cytostatic antitumor activity in mut-KRas(G12S) A549 xenograft and mut-KRasG12V H441 xenograft models.

Catalog No. 50-003-41975


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