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Medchemexpress LLC 1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea | 1454682-72-4 | MFCD28411374 | 98.7% | 424.51 g/mol | C23H29FN6O | 25MG
SDP

Supplier:  Medchemexpress LLC HY1255825MG

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LY3009120 (DP-4978) is a potent pan-RAF kinase inhibitor active against ARAF, BRAF (including V600E), and CRAF. It inhibits downstream MEK and ERK phosphorylation, shows antiproliferative effects in BRAF- and KRAS-mutant cell lines, and has demonstrated tumor regression in preclinical xenograft models. Supplied as a high-purity research compound with defined storage recommendations for powder and solvent formats.

  • Pan-RAF activity with low-nanomolar potency against BRAF V600E, BRAF wild-type, and CRAF.
  • Inhibits MEK and ERK phosphorylation downstream of RAF.
  • Antiproliferative in BRAF- and KRAS-mutant cell lines.
  • Produces tumor regression in preclinical xenograft models.
  • High purity and defined storage recommendations for powder and solvent preparations.

Catalog No. 50-002-37992


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