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Medchemexpress LLC 1-(4-(4-(2-((4-Chloro-3-(piperazin-1-ylsulfonyl)phenyl)amino)pyrimidin-4-yl)pyridin-2-yl)phenyl)-3-methyl... | 3056394-59-0 | 99.1% | 579.07 | 5 MG
SDP

Supplier:  Medchemexpress LLC HY1611115MG

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KVS0001 is a selective SMG1 inhibitor that elevates the expression of transcripts and proteins resulting from truncating mutations. It increases the presentation of immune-targetable HLA class I-associated peptides from nonsense-mediated decay (NMD)-downregulated proteins on the surface of cancer cells. KVS0001 exhibits anti-tumor properties and is suitable for research in NMD-related diseases, including cancer and inherited diseases.

  • Selectively inhibits SMG1 protein over 246 other protein or lipid kinases.
  • Elevates the expression of transcripts and proteins resulting from truncating mutations.
  • Enhances the presentation of immune-targetable HLA class I-associated peptides from NMD-downregulated proteins on cancer cell surfaces.
  • Exerts anti-tumor properties.
  • Can be studied in research for NMD-related diseases, including cancer and inherited diseases.

Catalog No. 50-003-92877


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