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Medchemexpress LLC 1-Azabicyclo[2.2.2]octan-3-one, 2,2-bis(hydroxymethyl)- | 5608-24-2 | 98.0% | 185.22 | 25 MG
SDP

Supplier:  Medchemexpress LLC 25MGHY19980A

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PRIMA-1 is a mutant p53 reactivator that restores the sensitivity of TP53 mutant-type thyroid cancer cells to the histone methylation inhibitor 3-Deazaneplanocin A.

  • Reactivates mutant p53, restoring sensitivity in TP53 mutant-type thyroid cancer cells.
  • Significantly suppresses lung adenocarcinoma formation in mice.
  • Shows in vitro activity with IC50 values ranging from 35 to 75 μM in various cell lines.
  • Demonstrates in vivo activity, suppressing lung adenocarcinoma formation.

Catalog No. 50-004-02732


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