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Medchemexpress LLC 1-Azakenpaullone | 676596-65-9 | >99.6% | C15H10BrN3O | 25 MG
Supplier: Medchemexpress LLC 25MGHY59090
1-Azakenpaullone (1-Akp) is a highly selective, ATP-competitive inhibitor of glycogen synthase kinase-3 β (GSK-3β) with an IC50 of 18 nM. For research use only, it stimulates proliferation in irradiated zebrafish lateral line neuromasts and induces osteoblastic differentiation and mineralization of human mesenchymal stem cells (MSCs) via Wnt signaling. In vivo, it reverses ketamine-induced locomotor hyperactivity in male NMRI mice.
- Highly selective and ATP-competitive inhibitor of glycogen synthase kinase-3 β (GSK-3β)
- Exhibits an IC50 value of 18 nM
- Stimulates proliferation in irradiated zebrafish lateral line neuromasts
- Induces osteoblastic differentiation and mineralization of human mesenchymal stem cells (MSCs)
- Activates Wnt signaling
- Reduces S6K1 phosphorylation in HCC1806 cells
- Reverses ketamine-induced locomotor hyperactivity and behavioral aberrations in male NMRI mice
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