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Medchemexpress LLC 1-Benzyl 7-methyl 6-((4-chlorophenyl)sulfonyl)-4,5-dioxopyrrolo[3,2-e]indole dicarboxylate | 2304465-89-0 | C26H17ClN2O8S | 5 MG
SDP

Supplier:  Medchemexpress LLC HY1501905MG

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F5446 is a selective small molecule inhibitor of SUV39H1 methyltransferase. It decreases H3K9me3 deposition at the FAS promoter, increases Fas expression, and enhances colorectal carcinoma cell sensitivity to FasL-induced apoptosis in vitro. This compound also suppresses human colon tumor xenograft growth in vivo.

  • Selective SUV39H1 methyltransferase inhibitor
  • Decreases H3K9me3 deposition at the FAS promoter
  • Increases Fas expression
  • Enhances colorectal carcinoma cell sensitivity to FasL-induced apoptosis in vitro
  • Suppresses human colon tumor xenograft growth in vivo
  • Induces apoptotic cell death in SW620 and LS411N cells
  • Up-regulates tumor cell surface Fas expression
  • Induces human colon tumor cell cycle arrest and apoptosis

Catalog No. 50-003-75617


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