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Medchemexpress LLC 1-Benzyl-I3C | 60941-76-6 | 237.30 | 1 MG
Supplier: Medchemexpress LLC HYN101591MG
1-Benzyl-I3C is a NEDD4-1 inhibitor that exhibits significant anticancer activity. It directly inhibits the ubiquitination activity of NEDD4-1 with an IC50 of 12.3μM, which is significantly better than its precursor compound I3C (IC50 of 284μM). 1-Benzyl-I3C and its analogs have shown good effects in inhibiting the proliferation of human melanoma cells. In vitro ubiquitination experiments and thermal stability analysis indicate that 1-Benzyl-I3C binds to the catalytic HECT domain of NEDD4-1.
- Nedd4-1 inhibitor
- Significant anticancer activity
- Inhibits proliferation of human melanoma cells
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