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Medchemexpress LLC 1-Butanol, 2-[[9-(1-methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-, (2R)- | 866893-90-5 | 98.4% | 368.48 | 10 MG
SDP

Supplier:  Medchemexpress LLC HY11126710MM/1ML

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Aftin-4 is an Amyloid-β42 (Aβ42) inducer for research use only. It selectively and potently increases Aβ1-42 in N2a cells, primary neurons, and brain lysates, with an EC50 value around 30 μM. It can also increase Aβ1-42 levels in vivo in mice, provoking sustained toxicity reminiscent of Alzheimer's disease (AD). Administered into the lateral ventricle, it results in a dose-dependent increase in Aβ1-42 content (up to +216% at the highest dose). It can also be injected intraperitoneally (i.p.).

  • Selectively and potently increases Aβ1-42 in N2a cells, primary neurons, and brain lysates.
  • Increases Aβ1-42 levels in vivo in mice.
  • Provokes sustained toxicity reminiscent of Alzheimer's disease (AD).
  • Administered at increasing doses (3 to 20 nmol/mouse) into the lateral ventricle.
  • Can also be injected intraperitoneally (i.p.) in mice.

Catalog No. 50-003-43860


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