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Medchemexpress LLC 1-Naphthalenecarboxaldehyde, 2-hydroxy-, S-(4-methylphenyl)thiooxime | 906439-72-3 | 99.9% | 250 MG
Supplier: Medchemexpress LLC 250MGHY128760
COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC50 of 0.37 nM. It binds to the catalytic domain of PARG, which prolongs PARylation at DNA lesions and traps DNA repair factors. This compound efficiently kills PARP inhibitor-resistant cancer cells and induces lethality in cancer cells with DNA repair defects, exhibiting antitumor activity in xenograft mouse cancer models. It is intended for research use only.
- Potent and specific PARG inhibitor with an IC50 of 0.37 nM
- Binds to the catalytic domain of PARG (Kd=0.547 μM)
- Efficiently kills PARP inhibitor-resistant cancer cells
- Induces lethality in cancer cells with DNA repair defects
- Exhibits antitumor activity in xenograft mouse cancer models
- For research use only
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