Medchemexpress LLC 1-Piperazinecarboxylic acid, 4-[[4-(4-chlorophenoxy)-3,5-difluorophenyl]sulfonyl]-3-[(hydroxyamino)ca | 1224964-36-6 | 98.25% | 548.92 | 100 MG

Supplier:  Medchemexpress LLC HY19485100MG

XL-784 is a selective inhibitor of matrix metalloproteinases (MMP). It shows IC50 values of approximately 1900, 0.81, 120, 10.8, 18, and 0.56 nM for MMP-1, MMP-2, MMP-3, MMP-8, MMP-9, and MMP-13, respectively. XL-784 is a highly potent, low-molecular-weight (1,122 g/mol) MMP inhibitor with limited aqueous solubility (20 μg/mL). It potently inhibits MMP-2, MMP-13, and ADAM10 [TNF-α-converting enzyme (TACE)] activity in vitro, with IC50 values in the range of 1-2 nM. XL-784 also inhibits MMP-9 (IC50 ~20 nM) and ADAM17 (IC50 ~70 nM) activity, but exhibits low potency for MMP-1 inhibition (IC50 ~2,000 nM). In vivo studies show that XL-784 is effective in inhibiting aortic dilatation in mice.

• Selective matrix metalloproteinases (MMP) inhibitor
• Potently inhibits MMP-2, MMP-13, and ADAM10 in vitro
• Inhibits MMP-9 and ADAM17 in vitro
• Effective in inhibiting aortic dilatation in vivo

Catalog No. 50-004-03415