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Apexbio Technology LLC 10058-F4 403811-55-2 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A11695.1
10058-F4 (CAS 403811-55-2) is a small molecule inhibitor targeting the transcription factor c-Myc It disrupts the dimerization of c-Myc with Max thereby preventing the c-Myc/Max complex from binding to DNA This disruption impairs c-Myc-dependent transcriptional activity leading to inhibited proliferation and induction of apoptosis in leukemia cells as evidenced by Bcl-2 downregulation Bax upregulation and cytochrome c release 10058-F4 has also been shown to suppress growth factor-induced expression of PGC-1 implicating c-Myc in related transcriptional events Additionally in lymphoma cells it reduces c-Myc mRNA levels The compound is widely used in research to investigate c-Myc function in oncogenesis and cellular metabolism
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