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Cayman Chemical 11a-Hydroxyprogesteron 1g
Supplier: Cayman Chemical 358981 G
An 11-HSD inhibitor (IC50s = 0.63 and 0.4 µM for recombinant human 11β-HSD1 and 11β-HSD2, respectively) and a derivative of progesterone; reduces urinary sodium excretion in male adrenalectomized rats when administered at 10, 100, and 500 UG/animal in combination with corticosterone but not when administered alone; potentiates corticosterone-induced increases in urinary potassium in male adrenalectomized rats when administered at 10, 100, and 500 UG/animal but has no effect on urinary potassium excretion when administered alone; increases blood pressure in rats at 10 UG/hour, s.c., an effect that can be blocked by adrenalectomy or reduced by co-administration of RU-28318; has been used as a precursor in the synthesis of various steroids
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