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Cayman Chemical 14 15EpETE Fatty Acids and Der
Supplier: Cayman Chemical 10173100 UG
EDHF is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (NO) and COX-derived (prostacyclin) vasodilators.{6485,7204} CYP450 metabolism of PUFAs, produces epoxides such as (±)14(15)-EpETrE which are prime candidates for the actual active mediator.{5826} However, the CYP450 metabolites of EPA (Item No. 90110) and DHA (Item No. 90310) have been little studied relative to arachidonate epoxygenase metabolites. (±)14(15)-EpETE is the ω-3 homolog of (±)14(15)-EpETrE, derived via epoxidation of the 14,15-double bond of EPA. The EDHF activity of (±)14(15)-EpETE has not yet been determined.
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