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Apexbio Technology LLC 1400W dihydrochloride 214358-33-5 100mg
Supplier: Apexbio Technology LLC B6730100
1400W dihydrochloride (CAS 214358-33-5) is a potent selective inhibitor of inducible nitric oxide synthase (iNOS) characterized by a slow reversible binding with a Kd of 7 nM iNOS generates nitric oxide (NO) involved in immune responses and inflammatory processes 1400W selectively inhibits iNOS over neuronal NOS (nNOS) and endothelial NOS (eNOS) with Ki values of 2 M and 50 M respectively In animal models 1400W reduces lesion size in ischemic brain injury and impedes tumor growth highlighting its utility for investigating inflammatory and pathological roles of NO production in biomedical research
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