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Medchemexpress LLC 1H-1,2,4-Triazol-3-amine, 5-[4-[(2S,5S)-5-[(4-chlorophenyl)methyl]-2-methyl-4-morpholinyl]... | 2088453-21-6 | 99.9% | 390.91 | 1 ML
SDP

Supplier:  Medchemexpress LLC HY137464A10MM/1ML

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OATD-01 is a highly potent, first-in-class, orally active, and selective chitinase inhibitor. It demonstrates low nanomolar activity towards CHIT1 and exhibits an excellent pharmacokinetic profile across multiple species. This compound shows significant antifibrotic efficacy in vivo and is being investigated for pulmonary fibrosis (IPF) research.

  • Highly potent and selective chitinase inhibitor
  • Low nanomolar activity towards CHIT1 (hCHIT1, IC50=23 nM)
  • Excellent pharmacokinetic profile across multiple species
  • Selective against a panel of off-targets
  • Significant antifibrotic efficacy in vivo
  • Suitable for pulmonary fibrosis (IPF) research
  • Exhibits high affinity toward h/mCHIT1 and h/mAMCase
  • Reduced lung fibrosis in animal models
  • Clinical trials are underway for pulmonary sarcoidosis (Phase 2)

Catalog No. 50-003-51823


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