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Medchemexpress LLC 1H-Imidazole, 2-[2-[2-(5-bromo-2-methoxyphenyl)ethyl]-3-fluorophenyl]-4,5-dihydro-, hydrochloride | 1706524-94-8 | 99.3% | 413.71 | 100 MG
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Supplier:  Medchemexpress LLC HY11012310MG

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ML-00253764 hydrochloride is a brain penetrant nonpeptidic melanocortin receptor 4 (MC4R) antagonist with a Ki and IC50 of 0.16 μM and 0.103 μM, respectively. It can cross the blood-brain barrier.

  • Brain penetrant nonpeptidic melanocortin receptor 4 (MC4R) antagonist.
  • Displaces NDP-α-MSH binding with varying IC50 values for hMC4-R, hMC3-R, and hMC5-R.
  • Decreases cAMP production induced by [NLE4,D-Phe7]-α-melanocyte stimulating hormone ([NDP]-α-MSH) in MC4R-expressing HEK293 cell membranes.
  • Shows protection against tumor-induced body weight loss in CT-26 tumor bearing BALB/c mice.

Catalog No. 50-003-44739


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