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Medchemexpress LLC 1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime) | 668467-91-2 | 98.9% | 397.64 | 1 ML
SDP

Supplier:  Medchemexpress LLC HY1863710MM/1ML

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LDN-57444 is a reversible, competitive, and site-directed inhibitor of ubiquitin C-terminal hydrolase L1 (UCH-L1) with an IC50 of 0.88 μM and a Ki of 0.40 μM. It also suppresses UCH-L3 activity, with an IC50 of 25 μM.

  • Inhibits UCH-L1 with high potency (IC50 of 0.88 μM, Ki of 0.40 μM) and suppresses UCH-L3 activity (IC50 of 25 μM).
  • Inhibits 70% of Uch activity in hippocampal slices of mouse brain at 5 μM for 1 hour.
  • Inhibits ubiquitin-proteasome activity dose-dependently (25-100 μM) in SK-N-SH cells.
  • Induces apoptotic cell death, causes endoplasmic reticulum stress, and results in expression of spliced XBP-1 in SK-N-SH cells at 50 μM.
  • Blocks the beneficial effect of V-Uch-L1 and worsens contextual conditioning performance in mice at 0.4 mg/kg (intraperitoneal injection).
  • Purity: 98.93%.

Catalog No. 50-003-87735


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