Medchemexpress LLC 1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime) | 668467-91-2 | 98.93% | 397.64 | 25 MG

Supplier:  Medchemexpress LLC 25MGHY18637

LDN-57444 is a reversible, competitive, and site-directed inhibitor of ubiquitin C-terminal hydrolase L1 (UCH-L1), with an IC50 of 0.88 μM and a Ki of 0.40 μM. It also suppresses UCH-L3 activity, with an IC50 of 25 μM.

• Inhibits 70% of Uch activity in hippocampal slices of mouse brain at 5 μM for 1 hour.
• Does not further reduce potentiation in APP/PS1 slices or in wt slices exposed to 200 nM Aβ at 5 μM for 2 hours.
• Inhibits ubiquitin-proteasome activity dose-dependently in SK-N-SH cells at 25-100 μM.
• Induces apoptotic cell death, causes endoplasmic reticulum stress, and results in expression of spliced XBP-1 (XBP-1s, 48KD) in SK-N-SH cells at 50 μM.
• Blocks the beneficial effect of V-Uch-L1 and worsens contextual conditioning performance in mice when administered at 0.4 mg/kg (i.p.) and exposed to the context at 1, 7, 14, and 21 days after training.

Catalog No. 50-003-84533