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Medchemexpress LLC 1H-pyrazolo[3,4-d]pyrimidine, 4-(1-azetidinyl)-1-methyl-3-[1-methyl-5-[4-(trifluoromethyl)phenyl] | 1415637-72-7 | 99.5% | 413.40 g·mol⁻¹ | C20H18F3N7 | 5 MG
SDP

Supplier:  Medchemexpress LLC HY1020505MG

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PF-05085727 is a potent, selective, brain-penetrant inhibitor of cGMP-dependent phosphodiesterase 2A (PDE2A) with an IC50 of 2 nM. Supplied as research-grade material in solid form and as a DMSO solution, it is suitable for in vitro and in vivo studies of PDE2A signaling and CNS pharmacology.

  • Potent PDE2A inhibition (IC50 = 2 nM).
  • High selectivity: >4,000-fold versus PDE1 and PDE3-11.
  • Brain penetrant, suitable for CNS pharmacology studies.
  • Available as solid (5-200 mg) and 10 mM solution in DMSO.
  • High chemical purity (~99.5%).
  • Useful tool compound for studying cGMP signaling and PDE2A-related biology.

Catalog No. 50-002-49033


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