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Medchemexpress LLC 2-[3-(3,5-dimethyltriazol-4-yl)-5-[(S)-oxan-4-yl(phenyl)methyl]pyrido[3,2-b]indol-7-yl]propan-2-ol | 1800340-40-2 | MFCD31544327 | 99.8% | 495.6 g/mol | C30H33N5O2 | 1 MG
SDP

Supplier:  Medchemexpress LLC HY1015671MG

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BMS-986158 (ezobresib) is an orally active small-molecule inhibitor of BET bromodomains used in oncology research. It binds the acetyl-lysine recognition pocket on BET proteins to disrupt chromatin-mediated transcription of oncogenes and has advanced into early clinical studies for hematologic and solid tumor indications.

  • Potent cell-based activity (low-nanomolar IC50s in several cancer cell lines)
  • BET bromodomain mechanism reduces expression of growth-promoting genes
  • Demonstrated activity in small cell lung and triple-negative breast cancer models
  • High chemical purity suitable for research applications
  • Supplied in milligram quantities for preclinical experiments
  • Chemical identifiers: CAS 1800340-40-2; formula C30H33N5O2

Catalog No. 50-002-48947


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