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Medchemexpress LLC 2-(4-ethyl-piperazin-1-yl)-N-[4-(2-morpholinyl-4-oxo-4H-chromen-8-yl)-dibenzothiophenyl]-acetamide | 881375-00-4 | MFCD17214218 | ≥97.0% | 582.71 g/mol | C33H34N4O4S | 5 MG
SDP

Supplier:  Medchemexpress LLC HY134315MG

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KU-0060648 is a small-molecule, ATP-competitive dual inhibitor of phosphoinositide 3-kinases (PI3K) and DNA-dependent protein kinase (DNA-PK), used in research to probe PI3K/DNA-PK signaling and to enhance chemosensitivity in cancer models. Reported enzymatic IC50 values are PI3Kα 4 nM, PI3Kβ 0.5 nM, PI3Kγ 0.1 nM, PI3Kδ 0.594 nM, and DNA-PK 8.6 nM.

  • Dual inhibition of PI3K and DNA-PK for pathway interrogation.
  • Low nanomolar potency against multiple PI3K isoforms and DNA-PK.
  • Suitable for use in in vitro and in vivo research studies.
  • Available in small-mass quantities for dose-ranging experiments.
  • Powder form with defined storage conditions to preserve stability.
  • Well-characterized chemical identity and molecular properties.

Catalog No. 50-002-22137


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