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Medchemexpress LLC 2,4-Pyrimidinediamine, N4-(cyclopropylmethyl)-6-[(3R)-3-(methylamino)-1-pyrrolidinyl]-, hydrochloride | 2096455-90-0 | 98.0% | 371.74 | 50 MG
SDP

Supplier:  Medchemexpress LLC HY19705B50MG

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Adriforant hydrochloride (PF-3893787 hydrochloride) is a novel histamine H4 receptor antagonist. It exhibits a binding affinity (Ki) of 2.4 nM and a functional (Ki) antagonist at 1.56 nM, making it suitable for research use.

  • Novel histamine H4 receptor antagonist.
  • Binding affinity (Ki) of 2.4 nM for H4R.
  • Functional (Ki) of 1.56 nM for H4R.
  • Fast on/fast off characteristic on rhH4R.
  • In vitro IC50 on human native isolated eosinophils assessing actin polymerisation is 1.16 nM.
  • Completely blocks imetit-induced shape change in whole blood GAFS assay at 30 nM total blood concentration.

Catalog No. 50-004-02746


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