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Cayman Chemical 2 5dimethyl Celecoxib
Supplier: Cayman Chemical 1000800625 MG
An anticancer celecoxib derivative; does not inhibit COX-2 (IC50 = >100 µM); inhibits mPGES-1 in HeLa cells (IC50 = 15.6 µM); reduces PGE2 production in HeLa, A549, and HCA-7 cells (IC50s = 0.64, 0.83, and 3.08 µM, respectively); inhibits proliferation of drug-sensitive RPMI8226 and multidrug-resistant 8226/Dox40 multiple myeloma cells; increases the rate of apoptosis in RPMI8226 and 8226/Dox40 cells at 20 and 30 µM; the antiproliferative effect of 2,5-dimethyl celecoxib is independent of mPGES-1 inhibition
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