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Medchemexpress LLC 2'-Azido-2'-deoxycytidine | 51034-68-5 | MFCD00043047 | C9H12N6O4 | 200 MG
Supplier: Medchemexpress LLC HY152448200MG
2'-Azido-2'-deoxycytidine is a purine nucleoside analogue with broad antitumor activity, especially against indolent lymphoid malignancies. Its anticancer mechanisms include inhibiting DNA synthesis and inducing apoptosis. It also functions as a click chemistry reagent, capable of copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne groups and strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. This azidonucleoside requires diphosphorylation to inhibit nucleotide reductase.
- Broad antitumor activity
- Targets indolent lymphoid malignancies
- Inhibits DNA synthesis and induces apoptosis
- Functions as a click chemistry reagent
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
- Requires diphosphorylation for nucleotide reductase inhibition
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