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Medchemexpress LLC 2-chloro-N-(3,4-dimethoxybenzyl)acetamide | 65836-72-8 | MFCD01733639 | 98.8% | 243.69 g/mol | C11H14ClNO3 | 1 ML
Supplier: Medchemexpress LLC HY10183610MM 1ML
DKM 2-93 is a covalent, relatively selective inhibitor of UBA5 that impairs pancreatic cancer cell survival by modifying the enzyme's catalytic cysteine. It inhibits UBA5 with an IC50 of 430 μM and demonstrates cellular activity in pancreatic cancer cell lines and in vivo tumor models.
- Inhibits UBA5 (IC50 430 μM).
- Shows cellular activity (PaCa2 IC50 90 μM; Panc1 IC50 30 μM).
- Covalent mechanism targeting the catalytic cysteine.
- Molecular formula C11H14ClNO3; molecular weight 243.69 g/mol.
- High purity (98.8%).
- Available as 10 mM solution in 1 mL DMSO and as solid; DMSO solubility up to 125 mg/mL.
- Storage: powder -20°C (3 years); solution -80°C (2 years).
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