Glen Research 2'-F-G-CE Phosphoramidite, 0.5 g, Guanosine, 2'-Fluoro, CE (β-cyanoethyl)

Supplier:  Glen Research 10342005E

This product is a 2'-Fluoro Guanosine CE Phosphoramidite, supplied by Glen Research, designed for oligonucleotide synthesis. It features a 2'-fluoro modification that enhances the thermal stability of duplexes with RNA by approximately 2°C per residue. This phosphoramidite is optimized for efficient synthesis and contributes to the development of chimeric oligonucleotides that bind tightly to RNA targets and resist nuclease degradation, particularly with phosphorothioate linkages.

• Enhances thermal stability of duplexes with RNA by ~2°C per residue
• Optimized for reliable synthesis of oligonucleotides
• Chimeric 2'-F-RNA/DNA phosphorothioate exhibits RNase H activity
• Highly resistant to nucleases with phosphorothioate linkages
• Coupling time is 3 minutes recommended
• Deprotection requires Ammonium Hydroxide for 17 hours at 55°C
• Maintains base pair specificity

Catalog No. NC3673059