Medchemexpress LLC 2-methylsulfanyl-6-[4-[3-[3-(trifluoromethyl)anilino]-1H-1,2,4-triazol-5-yl]phenoxy]pyrimidin-4-amin | 877874-85-6 | MFCD22124522 | 99.8% | 459.45 | C20H16F3N7OS | 10 MG

Supplier:  Medchemexpress LLC HY1519810MG

KG5 is an orally active small-molecule allosteric inhibitor that targets PDGFRβ and B-Raf, with additional inhibitory activity against Flt3, KIT, and c-Raf. It demonstrates anticancer and antiangiogenic effects in cellular and animal models, including inhibition of MEK/ERK signaling and suppression of tumor growth and angiogenesis in vivo.

• Orally active allosteric inhibitor of PDGFRβ and B-Raf.
• Also inhibits Flt3, KIT, and c-Raf, broadening kinase coverage.
• Demonstrated anticancer and antiangiogenic activity in vitro and in vivo.
• Disrupts MEK/ERK phosphorylation and blocks S338 phosphorylation in endothelial cells.
• Potent cellular activity with EC50 values near 0.5-0.6 μM in vascular and endothelial cells.
• High purity suitable for research applications.
• Soluble in DMSO at high concentration and formulatable for in vivo dosing.
• Stable under recommended storage conditions to preserve activity.

Catalog No. 50-002-87497