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Medchemexpress LLC 2-Oxa-5-azabicyclo[2.2.1]heptane, 5-[2-[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-6-[6-(4-methoxy-3-pyri | 2769715-68-4 | 99.3% | 592.69 | 25 MG
SDP

Supplier:  Medchemexpress LLC 25MGHY161275

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BI-4732 is an orally active, reversible, ATP-competitive EGFR inhibitor with blood-brain barrier penetration. It inhibits the kinase activity of EGFR L858R, T790M, and C797S with IC50 values of 1 nM, while sparing wild-type EGFR. BI-4732 inhibits EGFR and reduces the phosphorylation of AKT, ERK, and S6K. It demonstrates excellent intracranial anti-tumor efficacy in a YU-1097 xenograft model, making it suitable for studying non-small cell lung cancer (NSCLC).

  • Orally active
  • Reversible
  • ATP-competitive EGFR inhibitor
  • Blood-brain barrier penetration
  • Inhibits kinase activity of EGFR L858R, T790M, and C797S with IC50 values of 1 nM
  • Spares wild-type EGFR
  • Reduces phosphorylation of AKT, ERK, and S6K
  • Demonstrates intracranial anti-tumor efficacy in YU-1097 xenograft model
  • Useful for the study of non-small cell lung cancer (NSCLC)

Catalog No. 50-003-92935


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