Medchemexpress LLC 2-pyridinecarboxamide, N-[4-[[3-[(1-oxo-2-propen-1-yl)amino]benzoyl]amino]phenyl]-6-(1H-pyrazol-3-yl) | 2227368-54-7 | MFCD34593626 | 99.0% | 452.46 g·mol-1 | C25H20N6O3 | 10 MG

Supplier:  Medchemexpress LLC HY103017A10MG

JH-X-119-01 is a small-molecule inhibitor selective for interleukin-1 receptor-associated kinase 1 (IRAK1). It demonstrates potent biochemical inhibition (IC50 ≈ 9 nM), shows no measurable IRAK4 inhibition up to 10 μM, and has reported efficacy in LPS-induced sepsis models. The compound is supplied as a high-purity research reagent in solid form or as a DMSO solution for experimental use.

• Potent IRAK1 inhibition (IC50 ≈ 9 nM).
• No measurable IRAK4 inhibition up to 10 μM.
• Demonstrated in vivo efficacy in LPS-induced sepsis models.
• High supplied purity (≈99.0%).
• Available as solid and 10 mM DMSO solution for easy dosing.
• Intended for research use only.

Catalog No. 50-002-47607