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Cayman Chemical 20carboxy Arachidonic Acid
Supplier: Cayman Chemical 10007912100 UG
The major metabolite of 20-HETE that is produced in renal tubular epithelial, endothelial, and microvascular smooth muscle cell cultures; ω-oxidation conversion can take place using purified alcohol dehydrogenases three and four or by microsomes containing recombinant human CYP4F3B; 20-carboxy arachidonic acid inhibits ion transport in the kidneys; produces vasorelaxation of porcine coronary microvessels constricted with endothelin; binds to isolated ligand binding domains of peroxisome proliferator-activated receptor α (PPARα) (Kd = 0.87 ± 0.12 µM) and PPARγ (Kd = 1.7 ± 0.5 µM); a dual activator of PPARα and PPARγ in a transiently transfected COS-7 cell reporter system
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