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Medchemexpress LLC 27-Hydroxycholesterol | 20380-11-4 | 25 MG
Supplier: Medchemexpress LLC 25MGHYN2371
27-Hydroxycholesterol (27-OHC) is a selective estrogen receptor modulator and an agonist of the liver X receptor. It is an endogenous oxysterol that regulates intracellular cholesterol homeostasis and is intended for research use only.
- Acts as an endogenous selective estrogen receptor modulator
- Functions as an agonist of the liver X receptor
- Positively regulates gene transcription and cell proliferation in breast cancer models
- Increases cell proliferation in LNCaP and PC3 cells
- Produced from cholesterol by monooxygenase CYP27A1
- Levels can be modulated by statins or CYP27A1 inhibition
- Important for LXR activation in response to cholesterol overload
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