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Medchemexpress LLC 27-Hydroxycholesterol | 20380-11-4 | 5 MG
Supplier: Medchemexpress LLC HYN23715MG
27-Hydroxycholesterol (27-OHC) is a selective estrogen receptor modulator and an agonist of the liver X receptor. It is an oxysterol produced from cholesterol by the monooxygenase CYP27A1, which regulates intracellular cholesterol homeostasis. This product is intended for research use only.
- Acts as an endogenous selective estrogen receptor modulator.
- Displays significant partial agonist activity in cellular models of estrogen receptor action.
- Positively regulates gene transcription and cell proliferation in breast cancer models.
- Triggers deleterious effects in prostate cancer cell lines, increasing cell proliferation.
- Can increase breast cancer growth and metastasis.
- Levels can be modulated by statins or direct inhibition of CYP27A1 to attenuate pro-tumorigenic activities.
- 27-hydroxylation of cholesterol is a key pathway for LXR activation in response to cholesterol overload.
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