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Medchemexpress LLC (2E)-5-phenyl-1-(2-thienyl)-2-penten-1-one | 1239987-91-7 | 99.8% | 242.34 g/mol | C15H14OS | 5 MG
SDP

Supplier:  Medchemexpress LLC HY1454685MG

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GPR52 antagonist-1 is a research-grade small-molecule antagonist of the G protein-coupled receptor GPR52. In preclinical studies it reduces mutant huntingtin (mHTT) levels and promotes survival of striatal neurons; it has been used in vivo to rescue Huntington's disease-related phenotypes in mouse models.

  • Potent GPR52 inhibition with IC50 0.63 μM.
  • Used in vivo: 5 mg/kg, i.p., once daily for 4 weeks in HdhQ140 mice.
  • High purity (99.8%) and solid appearance.
  • Molecular formula C15H14OS; molecular weight 242.34 g/mol.
  • Storage: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months) or -20°C (1 month).
  • Intended for research use; follow institutional safety and handling guidelines.

Catalog No. 50-002-21592


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