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Medchemexpress LLC 2H-1-Benzopyran-8-carboxaldehyde, 7-hydroxy-4-methyl-2-oxo- | 14003-96-4 | 99.65% | 204.18 | 10 MG
Supplier: Medchemexpress LLC 10MGHY19707
4μ8C (IRE1 Inhibitor III) is a small-molecule inhibitor of IRE1α. It inhibits Xbp1 splicing in ER stressed cultured cells in a concentration-dependent manner. This compound plays a role in cellular and in vivo research by modulating various biological activities related to ER stress and immune responses.
- Inhibits Xbp1 splicing in ER stressed cultured cells
- Prevents XBP1 mRNA splicing in response to ER stress
- Significantly inhibits IL-4, IL-5, and IL-13 production by CD4+ T cells
- Reduces atherosclerotic lesion area in ApoE-/- mice
- Mitigates plaque development
- Suppresses passive cutaneous anaphylaxis in mice
- Reverses ER stress-dependent loss of RIDD targets
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