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Medchemexpress LLC 2H-Dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxamide, 1,5-dihydro-2-imino-10-methyl-N-[3-(4-morpholinyl)propyl]-5-oxo-1-(2-phenylethyl)-, dihydrochloride | 99.70% | 573.51 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY122615B100MG

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SPOP-IN-6b dihydrochloride is a potent speckle-type POZ protein (SPOP) inhibitor with an IC50 of 3.58 μM. It is for research use only and not sold to patients. The product is provided as a solid with a light yellow to yellow color. The compound can suppress SPOP activity, leading to an increase in suppression cancer substrate protein PTEN and DUSP7 content in vitro.

  • Potent speckle-type POZ protein (SPOP) inhibitor
  • IC50 of 3.58 μM
  • Suppresses SPOP activity, increasing suppression cancer substrate protein PTEN and DUSP7 content in vitro with IC50s of 2-10.2 μM for A498, Caki-2, Ketr-3, 769-P, 0S-RC-2, and 786-0 cells
  • Can slow down tumor growth by suppressing SPOP in nude mice (40-80 mg/kg; intraperitoneal injection; daily; for 25 days)

Catalog No. 50-004-37391


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