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Medchemexpress LLC (2R)-1,1,1-trifluoro-2-[4-[(2S)-2-[[(3S)-3-methylmorpholin-4-yl]methyl]-4-thiophen-2-ylsulfonylpip... | 1361217-07-3 | >98.0% | 533.63 g·mol⁻¹ | C23H30F3N3O4S2 | 1MG
SDP

Supplier:  Medchemexpress LLC HY126141MG

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AMG-1694 is a small-molecule glucokinase-glucokinase regulatory protein (GK-GKRP) disruptor used as a biochemical research tool to promote dissociation of the GK-GKRP complex, increase glucokinase activity, and modulate glucose metabolism. It has potent biochemical activity (IC50 ≈ 7 nM) and has shown blood-glucose-lowering effects in diabetic rodent models.

  • Potent GK-GKRP disruption with low-nanomolar activity.
  • Increases glucokinase enzymatic activity and promotes translocation.
  • Demonstrated efficacy in rodent models for glycemic control.
  • Suitable for biochemical and cellular assays involving glucose metabolism.
  • Characterized chemical properties: molecular weight 533.63 g·mol⁻¹ and formula C23H30F3N3O4S2.

Catalog No. 50-002-34926


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