Medchemexpress LLC (2R)-5-(2-chlorophenyl)sulfanyl-4-hydroxy-2-(4-morpholin-4-ylphenyl)-2-thiophen-3-yl-1,3-dihydrop... | 2003234-63-5 | MFCD31560470 | 99.8% | 499.04 | C25H23ClN2O3S2 | 50 MG

Supplier:  Medchemexpress LLC HY100742A50MG

(R)-GNE-140 is the R-enantiomer of a potent lactate dehydrogenase A (LDHA) inhibitor used in biochemical and cellular research to probe LDH function and cancer metabolism. It exhibits nanomolar inhibition of LDHA and LDHB and has characterized purity, solubility, and storage properties suitable for in vitro and in vivo studies.

• Nanomolar inhibition of LDHA and LDHB (IC50 3 nM and 5 nM).
• R enantiomer is ~18-fold more potent than the S enantiomer.
• High chemical purity (99.77%) with enantiomeric excess ~99.14%.
• Solid, off-white to yellow appearance.
• Soluble in DMSO ≥ 50 mg/mL for in vitro use.
• Formulation suitable for in vivo dosing (≥ 2.5 mg/mL in 10% DMSO/40% PEG300/5% Tween-80/45% saline).
• Storage: powder at -20°C (stable for years) or 4°C for shorter term; in solvent store at -80°C or -20°C depending on duration.

Catalog No. 50-002-11918