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Medchemexpress LLC 3,4-Methylenedioxycinnamic acid | 2373-80-0 | MFCD00005837 | 99.7% | 192.17 | 5 G
Supplier: Medchemexpress LLC HYW0099935G
3,4-Methylenedioxycinnamic acid is an inhibitor of 4-hydroxycinnamoyl-CoA ligase (4CL) with a Ki of 100 μM. It exhibits a Km value for the substrate ferulic acid of 4CL at 8.4 μM. This compound increases the formation of soluble phenolics, particularly vanillic acid, and demonstrates larvicidal activity.
- Inhibitor of 4-hydroxycinnamoyl-CoA ligase (4CL).
- Increases the formation of soluble phenolics, particularly vanillic acid.
- Demonstrates larvicidal activity against Aedes aegypti.
- Exhibits cellular effects across multiple cell lines (HeLa, HepG2, MDCK, MT4, Oocyte, RAW264.7).
- Shows in vivo activity with mild central nervous system effects at 2000 mg/kg in female Swiss mice.
- Histological analysis showed no structural signs of toxicity in kidneys, liver, spleen, and lungs in tested animal models.
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