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Cayman Chemical 3-DeazaurIdIn 10mg
Supplier: Cayman Chemical 2312510 MG
A nucleoside analog; converted intracellularly to 3-deazauridine triphosphate, which inhibits the biosynthesis of CTP; inhibits the growth of L1210 leukemia cells when used at a concentration of 6 µM; dose-dependently reduces mortality in a mouse model of leukemia; enhances the incorporation of decitabine into DNA in leukemia cells when used at a concentration of 20 µM; reduces mortality when used at a dose of 100 or 150 mg/kg and combined with decitabine in a mouse model of leukemia
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