Medchemexpress LLC 3-Pyrrolidinecarboxamide, N-[2-(1H-imidazol-5-yl)ethyl]-1-(1H-indazol-3-yl)-5-oxo- | 1436004-46-4 | 99.73% | 1 ML

Supplier:  Medchemexpress LLC HY12942110MM/1ML

PA-9 is a pituitary adenylate cyclase-activating polypeptide (PACAP) type I (PAC1) receptor antagonist. It dose-dependently inhibits PACAP-induced cAMP elevation with an IC50 of 5.6 nM. This compound is used for research into neuropathic and inflammatory pain.

• Inhibits PACAP-induced cAMP elevation with an IC50 of 5.6 nM.
• Dose-dependently inhibits PACAP-induced CREB phosphorylation in CHO cells expressing PAC1 receptors.
• Attenuates PACAP-induced aversive responses and blocks mechanical allodynia in male ddY mice.
• Does not induce aversive responses or mechanical allodynia when administered alone.
• Well-accommodated in the PAC1 receptor subpocket, facilitating hydrophobic interactions.
• For powder, store at -20°C for 3 years or 4°C for 2 years.
• For solution, store at -80°C for 6 months or -20°C for 1 month.

Catalog No. 50-003-42911