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Sigma Aldrich Fine Chemicals Biosciences 3dGROTM R-Spondin-1 Condit
Supplier: Sigma Aldrich Fine Chemicals Biosciences SCM104
3D organoid culture systems are increasingly employed as powerful tools for the study of human diseases. R-Spondin proteins are a family of cysteine-rich thrombospondin type I repeat containing proteins that activate both the WNT/beta-catenin and WNT/PCP pathways. R-spondin-1 (RSPO1) is one of the most extensively used niche factors for culturing 3D organoids and has been used to establish organoids from the stomach small intestine colon pancreas and liver from both mouse and human sources1 2 3 along with intestinal organoids from other large and small animals4. However due to the high concentration requirement in organoid media the use of the recombinant R-spondin-1 becomes prohibitively expensive. The 3dGRO(TM) R-Spondin-1 Conditioned Media Supplement is a potent and inexpensive alternative to purified recombinant RSPO1 protein for organoid cultures and is optimized for the highest level of RSPO-1 expression to ensure consistency and performance. Note Product is supplied at a 2X
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