Medchemexpress LLC 4-(3-chloro-4-fluoroanilino)-6-(pyridin-3-ylmethylamino)-1,7-naphthyridine-3-carbonitrile | 871307-18-5 | MFCD12405303 | 99.4% | 404.83 g/mol | C21H14ClFN6 | 10MM 1ML

Supplier:  Medchemexpress LLC HY1235810MM 1ML

Tpl2 Kinase Inhibitor 1 is a small-molecule research reagent that selectively inhibits Tpl2 (MAP3K8) with biochemical potency (IC50 = 50 nM) and demonstrated cellular activity in monocytes and whole blood. It is supplied as a solid and as a ready-to-use 10 mM solution in DMSO for studies of MAP3K-dependent signaling and inflammatory responses.

• Selective Tpl2 inhibition with IC50 ≈ 50 nM.
• Inhibits LPS-induced TNF-alpha production in human monocytes (IC50 ~0.7-1.1 μM) and whole blood (IC50 8.5 μM).
• Chemical formula C21H14ClFN6; molecular weight 404.83 g/mol.
• High purity (~99.4%).
• Available as solid and as 10 mM solution in DMSO (1 mL).
• Storage: powder at -20 °C; in solvent at -80 °C (6 months) or -20 °C (1 month).
• Intended for use as a research tool to probe inflammatory and cancer-related signaling pathways.

Catalog No. 50-002-34917