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Medchemexpress LLC 4-[(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-8H-pyrimido[4,5-b]diazepin-2-yl)amino]-3-methoxy-... | 1062243-51-9 | MFCD22665717 | 99.5% | 543.61 g·mol⁻1 | C27H35F2N7O3 | 10 MG
SDP

Supplier:  Medchemexpress LLC HY1516110MG

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Ro3280 is a potent, highly selective small-molecule inhibitor of Polo-like kinase 1 (PLK1) used in preclinical research to study cell cycle regulation and anticancer mechanisms. It exhibits low-nanomolar biochemical potency and demonstrated cellular activity across multiple cancer cell lines.

  • Potent PLK1 inhibition with IC50 ≈ 3 nM and Kd ≈ 0.09 nM.
  • Demonstrated cellular activity in multiple cancer cell lines.
  • High reported purity (≈99.5%).
  • Solid form, off-white to yellow appearance.
  • Molecular weight 543.61 g·mol⁻1; formula C27H35F2N7O3.
  • Suitable for in vitro research on PLK1 biology and anticancer mechanisms.
  • Shows selectivity for PLK1 over PLK2 and PLK3.

Catalog No. 50-002-87291


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