Apexbio Technology LLC 4'-Demethylepipodophyllotoxin 6559-91-7 10mM (in 1mL DMSO)

Supplier:  Apexbio Technology LLC A31235.1

4 -Demethylepipodophyllotoxin (CAS 6559-91-7) is a small molecule structurally related to podophyllotoxin and serves as an intermediate in the synthesis of podophyllotoxin-derived compounds It exhibits pronounced cytotoxicity in vitro with EC50 values of 0 31 M in HL60 cells and 0 37 M in HepG2 cells after 48 hours as assessed by MTT assay Analogues such as 4-TMP-DMEP demonstrate even lower EC50 values (0 24 0 11 M) across multiple tumor cell lines reflecting enhanced potency compared to related compounds In in vivo studies pre-administration of this class of molecules has been shown to reduce tumor incidence growth and malignant conversion rates in animal models These properties support its utility in investigating mechanisms of tumor cytotoxicity and as a research scaffold in anticancer drug development

Catalog No. 50-000-95275