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Medchemexpress LLC 4-Methyl-2-oxopentanoic acid | 816-66-0 | 98.49% | 130.14 | 1 ML
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Supplier:  Medchemexpress LLC HYW01272210MM/1ML

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4-Methyl-2-oxopentanoic acid (α-Ketoisocaproic acid) is a metabolite of L-leucine involved in energy metabolism. It contributes to insulin resistance by impairing mTOR and autophagy signaling pathways and causes oxidative damage leading to cognitive deficits. This compound also functions as a nutrient signal, stimulating skeletal muscle protein synthesis.

  • Increases endoplasmic reticulum stress
  • Promotes lipid accumulation in preadipocytes
  • Inhibits α-ketoglutarate dehydrogenase activity
  • Acts as an oxidative phosphorylation uncoupler and metabolic inhibitor
  • Can be used in the study of maple syrup urine disease

Catalog No. 50-004-54915


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