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Medchemexpress LLC 4-Methyl-2-oxopentanoic acid | 816-66-0 | 99.51% | 130.14 | 100 MG
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Supplier:  Medchemexpress LLC HYW012722BS1100MG

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4-Methyl-2-oxopentanoic acid (α-Ketoisocaproic acid) is a metabolite of L-leucine involved in energy metabolism. It increases endoplasmic reticulum stress and promotes lipid accumulation in preadipocytes and insulin resistance by impairing mTOR and autophagy signaling pathways. It also causes oxidative damage, leading to cognitive deficits, inhibits α-ketoglutarate dehydrogenase activity, acts as an oxidative phosphorylation uncoupler and metabolic inhibitor. It acts as a nutrient signal and stimulates skeletal muscle protein synthesis.

  • Can be used in the study of maple syrup urine disease.
  • Increases endoplasmic reticulum stress.
  • Promotes lipid accumulation in preadipocytes.
  • Acts as an oxidative phosphorylation uncoupler.
  • Stimulates skeletal muscle protein synthesis.

Catalog No. 50-004-54914


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