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Cayman Chemical 4 MethylnItrosamIno1 3py 10mg
Supplier: Cayman Chemical 1641410 MG
A tobacco-specific nitrosamine carcinogen; metabolites induce DNA alkylation and methylation; increases the protein levels of DNMT1 in mouse bronchial epithelial cells within one day and increases hypermethylation of the tumor suppressor genes Chd13, Prdm2, and Runx3 in lung tissue at a single dose of 100 mg/kg; NNK induces adenomas and adenocarcinomas, which are present after 16 and 50 weeks, respectively, in mouse lung following a single dose of 10 µmol/animal; lifetime administration results in a 90% lung tumor incidence in rats at 63.5 mg/animal
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