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Medchemexpress LLC 4-Pyridinecarboxamide, N-[4-[5-(difluoromethoxy)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]- 3-fluoro- | 245747-71-1 | 99.4% | 416.28 | 1 ML
SDP

Supplier:  Medchemexpress LLC HY11277810MM/1ML

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NFAT Transcription Factor Regulator-1 is an IL-2 synthesis inhibitor with an IC50 of 182 nM. It inhibits human and rat PBMC proliferation with IC50s of 82 and 146 nM, respectively, and also inhibits IL-4 and IL-5 production in human T-cell lines. In vivo, it shows an inhibitory potency approximately 10-fold better than cyclosporine for blocking T-cell cytokine production, suggesting its potential for use in transplantation.

  • Inhibits IL-2, IL-4, and IL-5 synthesis
  • Inhibits human and rat PBMC proliferation
  • Better inhibitory potency than cyclosporine in vivo
  • Suitable for research into transplantation and immune system regulation

Catalog No. 50-004-38519


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