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ABclonal Technology 488 Rabbit anti-Human AGTR2
Supplier: ABclonal Technology A26592200T
This gene encodes a G-protein coupled receptor 1 family member serving as a receptor for angiotensin II It is an integral membrane protein highly expressed in fetuses and neonates but less so in adults except in the brain adrenal medulla and atretic ovary This receptor mediates programmed cell death playing a role in developmental biology and disease pathophysiology Mutations are linked to X-linked cognitive disability SARS-CoV and SARS-CoV-2 infections downregulate ACE2 receptors triggering inflammatory lesions particularly in the lungs The angiotensin AT2 receptor is upregulated in bronchoalveolar lavage samples from COVID-19 patients suggesting its role in inflammation
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