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ABclonal Technology 488 Rabbit anti-Human CD142
Supplier: ABclonal Technology A22492200T
This gene encodes coagulation factor III a cell surface glycoprotein essential for initiating blood coagulation It acts as a high-affinity receptor for factor VII forming a complex that triggers protease cascades via limited proteolysis Unlike other coagulation cofactors factor III is fully functional when expressed on cell surfaces such as on monocytes It has extracellular transmembrane and cytoplasmic domains Platelets and monocytes express this factor during procoagulatory and proinflammatory responses Factor III is implicated in HIV-related coagulopathy and is associated with COVID-19 severity and mortality Notably congenital deficiency of this protein has not been observed Multiple transcript variants exist due to alternative splicing
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